No. 24 LSU (5-2, 2-1 Southeastern Conference) is heading back to Mississippi for the second time this season to play Ole Miss (3-3, 1-2 SEC).
The Tigers are looking to pull off their third-straight conference win, one of which was on the road against Florida.
Orgeron: “I want this win for our players.”
This is going to be LSU coach Ed Orgeron’s first time back in Oxford as a head coach since his firing as the Rebels’ head coach following the 2007 season.
Orgeron worked his way back into the ranks, and held coaching jobs with the New Orleans Saints in the NFL and Tennessee, USC and LSU at the collegiate level.
Since being fired from Ole Miss, Orgeron said he has been back to Oxford two times prior to this weekend’s game, including as defensive coach for the Tigers in 2015.
“It’s another game for me, and I can honestly tell you that,” Orgeron said. “It’s another SEC game. I want this win for our players, whatever happened in Oxford is a long time ago. We’ve moved on.”
Health of Guice, Key, Weathersby
LSU is hoping for a full-go from junior running back Derrius Guice, junior outside linebacker Arden Key and right tackle Toby Weathersby.
Guice has been dealing with a nagging knee injury, and Orgeron believes “this is the healthiest Guice has been in a while.”
Without a fully healthy Guice, the Tigers’ running game has struggled at times. The team suffered an even bigger blow when they lost Weathersby against Florida, but the 6-foot-6, 308-pounder is expected to start at right tackle this weekend.
Orgeron hopes that Weathersby can play the full game but is not certain, and said they have to be prepared to spell him at certain times in the game. 
Must win for LSU
The Tigers need to come up with their first win in Oxford since 2011 if the team wants to keep the dreams of a meaningful postseason alive.
LSU has two bad losses, but still control its own fate in the SEC. If the Tigers lose to Ole Miss, they are almost assuredly eliminated from New Year Six bowl contention.
“It’s a must win,” Orgeron said. “A must win game for us, but we know we have to go over there, set out on that plane tomorrow and do a tremendous job.”
Orgeron described the game as a battle and said his players are ready for it.
“It’s LSU-Ole Miss,” Orgeron said. “It’s a rivalry game. This is for the fans, this is for the 70s, our players. This is for the Ronnie Estay sacking Archie Manning.”
“This is a battle of border states. Bragging rights. This is what college football is about.”