With a fully healthy Derrius Guice in the backfield, LSU hung 40 points on Ole Miss.
It was the first time a team led by Ed Orgeron scored 40 points in Oxford, and the first time since 2011 LSU won on the road against Ole Miss.
The Tigers abused the Ole Miss defense with a heavy dosage of Guice and senior running back Darrel Williams. The two combined for 493 all-purpose yards on 49 touches.
Guice finished with 276 yards rushing on 22 carries and one touchdown with nine yards receiving. Guice became the first player in Southeastern Conference history to rush for more than 250 yards in three games.
Williams finished with 105 yards receiving and 103 yards rushing, becoming the first LSU running back since Eddie Fuller in 1989 to catch 100 yards in a game.
Senior quarterback Danny Etling was 9-of-13 for 200 yards and two touchdowns. Etling also added a rushing touchdown to his tally.
The offense had to settle for four field goals in the game, and redshirt freshman Connor Culp delivered on all four. Culp became the first LSU kicker since Drew Alleman to make four field goals in a game. 
With the offense and Culp clicking, the Tiger defense was able to shut down a potent Ole Miss offense led by sophomore quarterback Shea Patterson. Things became easier for the Tigers when both Patterson and running back Jordan Wilkins suffered injuries in the first half.
Patterson and Wilkins continued to play after missing brief periods of time, but neither player was the same.
Junior outside linebacker Arden Key looked like he finally returned to his All-American form, coming up with six tackles and two sacks.
Freshman safety Grant Delpit, junior safety John Battle and junior cornerback Kevin Toliver all intercepted passes from Patterson. Patterson, the Southeastern Conference’s leading passer, finished the game 10-23 for 116 yards and no touchdowns.
LSU (6-2, 3-1 SEC) has a bye next weekend before heading to Tuscaloosa to play No. 1 Alabama (8-0, 5-0 SEC) on Nov. 4.